Lipocalin-2 negatively regulates epithelial-mesenchymal transition through matrix metalloprotease-2 downregulation in gastric cancer.

Sadaaki NishimuraYurie YamamotoAtsushi SugimotoShuhei KushiyamaShingo ToganoKenji KurodaTomohisa OkunoHiroaki KasashimaMasaichi OhiraKiyoshi MaedaMasakazu Yashiro

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2022)

LCN2 has a critical role in EMT signaling via MMP2 activity during GC progression. Thus, LCN2 might be a promising therapeutic target to revert EMT signaling in GC patients with poor outcomes.

Keyphrases

epithelial mesenchymal transition
signaling pathway
transforming growth factor
cell proliferation
gas chromatography
type diabetes
cell migration