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Pharmacokinetics of high-dose tigecycline in critically ill patients with severe infections.

Gennaro De PascaleLucia LisiGabriella Maria Pia CiottiMaria Sole VallecocciaSalvatore Lucio CutuliLaura CascaranoCamilla GelorminiGiuseppe BelloLuca MontiniSimone CarelliValentina Di GravioMario TumbarelloMaurizio SanguinettiPierluigi NavarraMassimo Antonelli
Published in: Annals of intensive care (2020)
The use of HD TGC is associated with satisfactory plasmatic and pulmonary concentrations for the treatment of severe infections due to fully susceptible bacteria (MIC < 0.5 mcg/mL). Even higher dosages and combination strategies may be suggested in presence of difficult to treat pathogens, especially in case of SSTI and IAI.
Keyphrases
  • high dose
  • early onset
  • pulmonary hypertension
  • antimicrobial resistance
  • gram negative
  • combination therapy
  • drug resistant
  • pseudomonas aeruginosa
  • cystic fibrosis