Haploidentical transplantation is associated with better overall survival when compared to single cord blood transplantation: an EBMT-Eurocord study of acute leukemia patients conditioned with thiotepa, busulfan, and fludarabine.

Federica GiannottiMyriam LabopinRoni ShouvalJaime SanzWilliam ArceseEmanuele AngelucciJorge SierraJosep-Maria Ribera SantasusanaStella SantaroneBruno BenedettoAlessandro RambaldiRiccardo SaccardiDidier BlaiseMichele Angelo CarellaVanderson RochaFrederic BaronMohamad MohtyAnnalisa RuggeriArnon Nagler

Published in: Journal of hematology & oncology (2018)

Our results suggest that TBF-MAC might allow for a potent graft-versus-leukemia, regardless of the alternative donor type. Furthermore, in patients receiving TBF-MAC, survival with NTD-Haplo may be better compared to SUCBT due to decreased NRM.

Keyphrases

cord blood
end stage renal disease
bone marrow
chronic kidney disease
ejection fraction
newly diagnosed
acute myeloid leukemia
peritoneal dialysis
prognostic factors
stem cell transplantation
high dose
acute lymphoblastic leukemia
patient reported outcomes