Population pharmacokinetic modelling of busulfan and the influence of body composition in paediatric Fanconi anaemia patients.
Matthijs W van HoogdalemChie EmotoTsuyoshi FukudaTomoyuki MizunoParinda A MehtaAlexander A VinksPublished in: British journal of clinical pharmacology (2020)
This is the first study to describe the population PK of busulfan in paediatric FA patients. The proposed model will facilitate PK model-informed precision dosing. FFM-based dosing is expected to improve the probability of achieving target Css , particularly in obese patients, while minimizing the risk of overdosing.
Keyphrases
- body composition
- end stage renal disease
- newly diagnosed
- obese patients
- ejection fraction
- chronic kidney disease
- intensive care unit
- emergency department
- prognostic factors
- peritoneal dialysis
- resistance training
- acute lymphoblastic leukemia
- patient reported outcomes
- allogeneic hematopoietic stem cell transplantation