Impaired immune tolerance mediated by reduced Tfr cells in rheumatoid arthritis linked to gut microbiota dysbiosis and altered metabolites.

Ruihe WuDongming WangLiyun ChengRui SuBaochen LiChunxue FanChong GaoCai-Hong Wang

Published in: Arthritis research & therapy (2024)

The breakdown of immune tolerance mediated by reduced Tfr cells was associated with the altered gut microbiotas and their metabolites implying the possible mechanism of RA pathogenesis from the perspective of microecology-metabolism-immune.

Keyphrases

rheumatoid arthritis
induced apoptosis
cell cycle arrest
ms ms
disease activity
endoplasmic reticulum stress
oxidative stress
cell death
signaling pathway
ankylosing spondylitis