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Impaired immune tolerance mediated by reduced Tfr cells in rheumatoid arthritis linked to gut microbiota dysbiosis and altered metabolites.

Ruihe WuDongming WangLiyun ChengRui SuBaochen LiChunxue FanChong GaoCai-Hong Wang
Published in: Arthritis research & therapy (2024)
The breakdown of immune tolerance mediated by reduced Tfr cells was associated with the altered gut microbiotas and their metabolites implying the possible mechanism of RA pathogenesis from the perspective of microecology-metabolism-immune.
Keyphrases
  • rheumatoid arthritis
  • induced apoptosis
  • cell cycle arrest
  • ms ms
  • disease activity
  • endoplasmic reticulum stress
  • oxidative stress
  • cell death
  • signaling pathway
  • ankylosing spondylitis