Cell signaling activation and extracellular matrix remodeling underpin glioma tumor microenvironment heterogeneity and organization.
Marija DinevskaSamuel S WidodoLiam FurstLucero CuzcanoYitong FangStefano MangiolaPaul J NeesonPhillip K DarcyRobert G RamsayRyan HutchinsonFabienne MacKayMichael ChristieStanley S StylliTheo MantamadiotisPublished in: Cellular oncology (Dordrecht) (2022)
The tumor microenvironment in malignant astrocytoma, exhibits changes in cell composition, cell signaling activation and extracellular matrix deposition during disease development and that targeting the extracellular matrix, as well as cell signaling activation will be critical to designing personalized therapy.