Precision Medicine With Leflunomide: Consideration of the DHODH Haplotype and Plasma Teriflunomide Concentration and Modification of Outcomes in Patients With Rheumatoid Arthritis.
Michael D WieseAshley M HopkinsCatherine KingMihir D WechalekarAnita LeeLlewellyn SpargoRobert MetcalfLeah McWilliamsCatherine L HillLeslie G ClelandSusanna M ProudmanPublished in: Arthritis care & research (2021)
Teriflunomide concentration and carriage of the DHODH haplotype 2 are associated with response to leflunomide in patients with RA, and a total plasma teriflunomide concentration of at least 16 mg/liter is needed to maximize the likelihood of response.