CDK4/6 Inhibition Suppresses p73 Phosphorylation and Activates DR5 to Potentiate Chemotherapy and Immune Checkpoint Blockade.
Jingshan TongXiao TanXiangping SongMan GaoDenise RisnikSuisui HaoKaylee ErminePeng WangHua LiYi HuangJian YuLin ZhangPublished in: Cancer research (2022)
This work demonstrates how inhibition of CDK4/6 sensitizes cancer cells to chemotherapy and immune checkpoint blockade and may provide a new molecular marker for improving CDK4/6-targeted cancer therapies. See related commentary by Frank, p. 1170.