T-Cell Dynamics in Chronic Lymphocytic Leukemia under Different Treatment Modalities.
Anna VardiElisavet VlachonikolaDespoina PapazoglouFotis E PsomopoulosKostantia KottaNikolaos IoannouChrysi GaligalidouKaterina GemenetziKostantinos PasentsisMaria KotouzaEvdoxia KoravouLydia ScarfóMichail IskasNiki StavroyianniPaolo GhiaAchilles AnagnostopoulosAnastasia KouvatsiAlan G RamsayKostas StamatopoulosAnastasia ChatzidimitriouPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
Taken together, our NGS immunoprofiling data suggest that BcRi retain T-cell clones that may have developed against CLL-associated antigens. Phenotypic and immune synapse bioassays support a concurrent restoration of functionality, mostly evident for R-ID, arguably contributing to clinical response.