Bisdemethoxycurcumin Attenuated Renal Injury via Activation of Keap1/Nrf2 Pathway in High-Fat Diet-Fed Mice.
Xiaoqin DingYan ChenLina ZhouRuoyun WuTun-Yu JianHan LyuYan LiuJian ChenPublished in: International journal of molecular sciences (2022)
Bisdemethoxycurcumin (BDMC), a principal and active component of edible turmeric, was previously found to have beneficial effects on metabolic diseases. Chronic kidney disease (CKD) may benefit from its potential therapeutic use. Using a high-fat diet (HFD)-fed mouse model, we examined the effects of BDMC on renal injury and tried to determine how its associated mechanism works. A number of metabolic disorders are significantly improved by BDMC, including obesity, hyperglycemia, hyperinsulinemia, hyperlipidemia and inflammation. Further research on renal histopathology and function showed that BDMC could repair renal pathological changes and enhance renal function. Moreover, decreased serum malondialdehyde (MDA), elevated superoxide dismutase (SOD) activity, and the inhibition of renal reactive oxygen species (ROS) overproduction revealed the alleviation of oxidative stress after BDMC administration. In addition, renal Kelch-like ECH-associated protein 1/nuclear factor erythroid 2-related factor 2 (Keap1/Nrf2) pathway was activated in BDMC-treated mice. In conclusion, these findings demonstrated BDMC as a potential therapy for HFD-induced CKD via the activation of the Keap1/Nrf2 pathway.
Keyphrases
- high fat diet
- oxidative stress
- insulin resistance
- chronic kidney disease
- adipose tissue
- high fat diet induced
- reactive oxygen species
- nuclear factor
- diabetic rats
- mouse model
- type diabetes
- metabolic syndrome
- skeletal muscle
- toll like receptor
- immune response
- ischemia reperfusion injury
- physical activity
- drug induced
- wild type
- newly diagnosed