Genetic characterization of suspected MODY patients in Tunisia by targeted next-generation sequencing.

Hamza DallaliSerena PezzilliMeriem HechmiOm Kalthoum SallemSahar ElouejHaifa JmelYosra Ben HalimaMariem CharguiMariem GharbiLuana MercuriFederica AlbericoTommaso MazzaAfaf BahlousMelika Ben AhmedHenda JamoussiAbdelmajid AbidVincenzo TrischittaSonia AbdelhakSabrina PrudenteRym Kefi

Published in: Acta diabetologica (2019)

Our study is the first to investigate the clinical application of targeted next-generation sequencing for the diagnosis of MODY in Africa. The combination of this approach with a filtering/prioritization strategy made a step towards the identification of MODY mutations in the Tunisian population.

Keyphrases

end stage renal disease
newly diagnosed
copy number
ejection fraction
cancer therapy
chronic kidney disease
peritoneal dialysis
pulmonary embolism
prognostic factors
circulating tumor
dna methylation
genome wide