Deficiency of WTAP in islet beta cells results in beta cell failure and diabetes in mice.
Xinzhi LiYing YangZhenzhi LiYuqin WangJingting QiaoZheng ChenPublished in: Diabetologia (2023)
The RNA-seq and MeRIP-seq datasets generated during the current study are available in the Gene Expression Omnibus database repository ( https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE215156 ; https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE215360 ).
Keyphrases
- endoplasmic reticulum stress
- rna seq
- induced apoptosis
- single cell
- gene expression
- type diabetes
- dna methylation
- cardiovascular disease
- cell therapy
- stem cells
- glycemic control
- genome wide
- adipose tissue
- cell cycle arrest
- cell death
- bone marrow
- mesenchymal stem cells
- cell proliferation
- replacement therapy
- insulin resistance
- smoking cessation