Hybrid Molecular and Functional Micro-CT Imaging Reveals Increased Myocardial Apoptosis Preceding Cardiac Failure in Progeroid Ercc1 Mice.
Bibi S van ThielMartine de BoerYanto RidwanMarion G J de KleijnenNicole van VlietJanette van der LindenIsa de BeerPaula M van HeijningenWilbert P VermeijJan H J HoeijmakersA H Jan DanserRoland KanaarDirk J DunckerIngrid van der PluijmJeroen EssersPublished in: Molecular imaging and biology (2024)
This study highlights the utility of combined functional micro-CT and FMT imaging in assessing cardiac function and detecting apoptosis, providing valuable insights into the potential of apoptosis as an early biomarker for cardiac failure.
Keyphrases
- endoplasmic reticulum stress
- oxidative stress
- cell cycle arrest
- left ventricular
- high resolution
- cell death
- computed tomography
- image quality
- contrast enhanced
- dual energy
- magnetic resonance imaging
- positron emission tomography
- heart failure
- pi k akt
- metabolic syndrome
- magnetic resonance
- risk assessment
- photodynamic therapy
- atrial fibrillation