DNA methylation profiles differ in responders versus non-responders to anti-PD-1 immune checkpoint inhibitors in patients with advanced and metastatic head and neck squamous cell carcinoma.

Angelika Martina Starzer Gerwin HellerErwin TomasichThomas MelchardtKatharina FeldmannTeresa HatziioannouStefan TraintChristoph MinichsdorferUrsula Schwarz-NemecMaja NackenhorstLeonhard MüllauerMatthias PreusserAnna Sophie BerghoffThorsten Fuereder

Published in: Journal for immunotherapy of cancer (2022)

Our findings suggest that tumor DNA methylation profiling may be useful to predict response to ICI in patients with HNSCC.

Keyphrases

dna methylation
genome wide
gene expression
squamous cell carcinoma
small cell lung cancer
copy number
single cell