Trypanosoma cruzi-specific IFN-γ-producing cells in chronic Chagas disease associate with a functional IL-7/IL-7R axis.

María Ailén NataleGonzalo CesarMaría G AlvarezMelisa D Castro EiroBruno LococoGraciela BertocchiMaría C AlbaredaSusana A Laucella

Published in: PLoS neglected tropical diseases (2018)

Alterations of the IL-7/IL-7R axis and in the levels of inflammatory cytokines were linked to impaired T. cruzi-specific IFN-γ production. These alterations might be responsible of the process of immune exhaustion observed in chronic Chagas disease.

Keyphrases

trypanosoma cruzi
immune response
induced apoptosis
cell cycle arrest
cell death
cell proliferation
oxidative stress