SMAD4: A Critical Regulator of Cardiac Neural Crest Cell Fate and Vascular Smooth Muscle Differentiation.

Brianna E AlexanderHuaning Zhao Sophie Astrof

Published in: bioRxiv : the preprint server for biology (2023)

Overall, this study demonstrates the critical role of SMAD4 in the survival of cardiac NCs, their differentiation to vSMCs, and their contribution to the developing pharyngeal arches.

Keyphrases

smooth muscle
cell fate
epithelial mesenchymal transition
transforming growth factor
left ventricular
heart failure
free survival
vascular smooth muscle cells