Integrative Network-Based Analysis Reveals Gene Networks and Novel Drug Repositioning Candidates for Alzheimer Disease.

Zachary F GerringEric R GamazonAnthony WhiteEske M Derks

Published in: Neurology. Genetics (2021)

Our results improve the biological interpretation of genetic data for Alzheimer disease and provide a list of potential antidementia drug repositioning candidates for which the efficacy should be investigated in functional validation studies.

Keyphrases

mild cognitive impairment
genome wide
copy number
electronic health record
adverse drug
drug induced
big data
gene expression
emergency department
machine learning
risk assessment
case control
climate change
artificial intelligence
high resolution
single molecule