First synthesis of (±)-myristicyclin A.
Shinichiro KuboNaoki MoriHidenori WatanabeHirosato TakikawaPublished in: Bioscience, biotechnology, and biochemistry (2018)
The first synthesis of myristicyclin A, which was isolated from the Papua New Guinean plant Horsfieldia spicata, is described. The synthesis features acid-mediated hydroarylation reaction to form a dihydrocoumarin moiety, construction of the 2,8-dioxabicyclo[3.3.1]nonane skeleton under acidic conditions, and regioselective Friedel-Crafts acylation at a later stage.
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