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Interventions for treatment of COVID-19: A living systematic review with meta-analyses and trial sequential analyses (The LIVING Project).

Sophie JuulEmil Eik NielsenJoshua Buron FeinbergFaiza SiddiquiCaroline Barkholt KampEmily BarotNiklas NielsenPeter BentzerAreti Angeliki VeronikiLehana ThabaneFanlong BuSarah KlingenbergChristian GluudJanus Christian Jakobsen
Published in: PLoS medicine (2020)
Our results show that dexamethasone and remdesivir might be beneficial for COVID-19 patients, but the certainty of the evidence was low to very low, so more trials are needed. We can exclude the possibility of hydroxychloroquine versus standard care reducing the risk of death and serious adverse events by 20% or more. Otherwise, no evidence-based treatment for COVID-19 currently exists. This review will continuously inform best practice in treatment and clinical research of COVID-19.
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