Molecular Programming of NIR-IIb-Emissive Semiconducting Small Molecules for In Vivo High-Contrast Bioimaging Beyond 1500 nm.
Yi YuanZhe FengShengliang LiZhongming HuangYingpeng WanChen CaoSien LinLan WuJing ZhouLiang-Sheng LiaoJun QianChun-Sing LeePublished in: Advanced materials (Deerfield Beach, Fla.) (2022)
Materials with long-wavelength second near-infrared (NIR-II) emission are highly desired for in vivo dynamic visualizating of microstructures in deep tissues. Herein, by employing an atom-programming strategy, a series of highly fluorescent semiconducting oligomers (SOMs) with tunable NIR-IIb emissions are developed for bioimaging applications. After self-assembly into nanoparticles (NPs), they show good brightness, high photostability, and satisfactory biocompatibility. The SOM NPs are applied as probes for high-resolution imaging of whole-body and hind-limb blood vessels, biliary tract, and bladder with their emissions over 1500 nm. This work demonstrates an atom-programming strategy for constructing semiconducting small molecules with enhanced NIR-II fluorescence for deep-tissue imaging, affording new insight for advancing molecular design of NIR-II fluorophores.
Keyphrases
- fluorescent probe
- photodynamic therapy
- living cells
- fluorescence imaging
- high resolution
- drug release
- single molecule
- quantum dots
- molecular dynamics
- gene expression
- light emitting
- spinal cord injury
- magnetic resonance
- mass spectrometry
- drug delivery
- small molecule
- computed tomography
- heavy metals
- municipal solid waste
- oxide nanoparticles
- label free