A Biomimetic Core-Shell Platform for Miniaturized 3D Cell and Tissue Engineering.

Pranay AgarwalJung Kyu ChoiHaishui HuangShuting ZhaoJenna DumbletonJianrong LiXiaoming He

Published in: Particle & particle systems characterization : measurement and description of particle properties and behavior in powders and other disperse systems (2015)

This article describes a biomimetic core-shell platform with a collagen-based core and an alginate hydrogel shell for cell and tissue culture. With this system, chemical and physical properties of extracellular matrix (ECM) in the core microenvironment can be controlled to regulate proliferation and development of cells/tissues under miniaturized three-dimensional (3D) culture.

Keyphrases

tissue engineering
extracellular matrix
single cell
cell therapy
induced apoptosis
stem cells
gene expression
physical activity
mental health
drug delivery
wound healing
oxidative stress
bone marrow
mesenchymal stem cells
cell proliferation
endoplasmic reticulum stress
hyaluronic acid