Germline sequencing for presumed germline pathogenic variants via tumor-only comprehensive genomic profiling.

Tomohiro KondoYoshihiro YamamotoKeita FukuyamaMasashi KanaiAtsushi YamadaJunichi MatsubaraPham Nguyen QuyMasahiro YoshiokaTakahiro YamadaSachiko MinamiguchiShigemi MatsumotoShinji KosugiManabu Muto

Published in: International journal of clinical oncology (2022)

Our current data suggested that the application of ESMO-PMWG criteria is helpful in selecting PGPVs with a high likelihood of germline origin in a tumor-only CGP in daily clinical practice.

Keyphrases

dna repair
clinical practice
copy number
single cell
big data
oxidative stress
genome wide