Synthetic Essentiality of Tryptophan 2,3-Dioxygenase 2 in APC-Mutated Colorectal Cancer.

Rumi LeeJiexi LiJun LiChang-Jiun WuShan JiangWen-Hao HsuDeepavali ChakravartiPeiwen Chen Kyle A LaBella Jing Li Denise J Spring Di Zhao Y Alan Wang Ronald A DePinho

Published in: Cancer discovery (2022)

This study identifies critical effectors in the maintenance of APC-deficient colorectal cancer and demonstrates the relationship between APC/WNT pathway and kynurenine pathway signaling. It further determines the tumor-associated macrophage biology in APC-deficient colorectal cancer, informing genotype-specific therapeutic targets and the use of TDO2 inhibitors. This article is highlighted in the In This Issue feature, p. 1599.

Keyphrases

stem cells
machine learning
adipose tissue
genome wide
deep learning
gene expression
dna methylation