Therapeutic Implications of COVID-19 for the Interventional Cardiologist.
Matthew KelhamFizzah A ChoudryStephen HamshereAnne-Marie BeirneKrishnaraj S RathodAndreas BaumbachAmrita AhluwaliaAnthony MathurDaniel A JonesPublished in: Journal of cardiovascular pharmacology and therapeutics (2020)
Although COVID-19 is viewed primarily as a respiratory disease, cardiovascular risk factors and disease are prevalent among infected patients and are associated with worse outcomes. In addition, among multiple extra-pulmonary manifestations, there has been an increasing recognition of specific cardiovascular complications of COVID-19. Despite this, in the initial stages of the pandemic there was evidence of a reduction in patients presenting to acute cardiovascular services. In this masterclass review, with the aid of 2 exemplar cases, we will focus on the important therapeutic implications of COVID-19 for interventional cardiologists. We summarize the existing evidence base regarding the varied cardiovascular presentations seen in COVID-19 positive patients and the prognostic importance and potential mechanisms of acute myocardial injury in this setting. Importantly, through the use of a systematic review of the literature, we focus our discussion on the observed higher rates of coronary thrombus burden in patients with COVID-19 and acute coronary syndromes.
Keyphrases
- coronavirus disease
- sars cov
- cardiovascular risk factors
- end stage renal disease
- newly diagnosed
- ejection fraction
- respiratory syndrome coronavirus
- acute coronary syndrome
- cardiovascular disease
- primary care
- percutaneous coronary intervention
- skeletal muscle
- adipose tissue
- climate change
- intensive care unit
- insulin resistance
- atrial fibrillation
- weight loss
- aortic dissection
- case report
- acute respiratory distress syndrome
- aortic stenosis
- human health