Pharmacogenetic profiling of dihydropyrimidine dehydrogenase (DPYD) variants in the Indian population.

Shaik Mohammad NaushadTajamul HussainSalman A AlrokayanVijay Kumar Kutala

Published in: The journal of gene medicine (2020)

We have identified four Level 1A (non-functional/dysfunctional) and seven Level 3 variants in the DPYD gene. The pooled Indian data revealed the association of V732I, S534N and rs3918290 variants with 5-FU/capecitabine toxicity. Clustering analysis revealed the similarities in the DPYD profiles of the Indian and South Asian populations.

Keyphrases

copy number
single cell
rna seq
genome wide
oxidative stress
big data
dna methylation
clinical trial
gene expression
squamous cell carcinoma
phase iii
machine learning
phase ii study
locally advanced
data analysis
study protocol