Fibrosis-related transcriptome unveils a distinctive remodeling matrix pattern in penetrating ileal Crohn's disease.

Helena Tavares de SousaMarta FerreiraIrene GulloAna Mafalda RochaAna PedroDina LeitãoCarla OliveiraFátima CarneiroFernando Magro

Published in: Journal of Crohn's & colitis (2024)

Despite the histopathological similarities in fibrosis between stricturing and penetrating ileal Crohn's disease, their fibrosis-related transcriptomic profiles are distinct. Penetrating disease exhibits a distinctive transcriptomic landscape related to enhanced matrix remodeling.

Keyphrases

single cell
rna seq
gene expression
dna methylation
drug induced