Development and Implementation of One-Step, Broad-Spectrum, High-Sensitivity Drug Screening by Tandem Mass Spectrometry in a Pediatric Population.
Merih T TesfazghiRick BardelmeierAl N SaundersSarah M RileyStephen M RoperDennis J DietzenPublished in: The journal of applied laboratory medicine (2022)
A broadly targeted, analytically sensitive LC-MS/MS drug screening assay detects a larger number and variety of compounds in a single step compared to a screen-then-confirm approach initiated by immunoassay in our pediatric population. Rapid delivery of accurate results enables timely, appropriate disposition of patients in a variety of settings including the emergency department and labor/delivery.
Keyphrases
- tandem mass spectrometry
- emergency department
- ultra high performance liquid chromatography
- end stage renal disease
- high performance liquid chromatography
- high throughput
- ejection fraction
- newly diagnosed
- high resolution
- primary care
- simultaneous determination
- healthcare
- gas chromatography
- adverse drug
- peritoneal dialysis
- prognostic factors
- cancer therapy
- patient reported outcomes
- drug delivery
- drug induced
- mass spectrometry
- quality improvement
- ms ms
- single cell