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Tumor-draining lymph node is important for a robust abscopal effect stimulated by radiotherapy.

Zachary S BuchwaldTahseen H NastiJudong LeeChristiane S EberhardtAndreas WielandSe Jin ImDavid LawsonWalter CurranRafi AhmedMohammad K Khan
Published in: Journal for immunotherapy of cancer (2021)
These correlative results suggest the tumor-draining LN may be an important mediator of the abscopal effect by serving as a stem-like CD8+ T-cell reservoir, a site for stem-like T-cell expansion, and a site from which they can populate the tumor.
Keyphrases
  • lymph node
  • early stage
  • radiation therapy
  • neoadjuvant chemotherapy
  • radiation induced
  • locally advanced
  • rectal cancer