Tumor-draining lymph node is important for a robust abscopal effect stimulated by radiotherapy.
Zachary S BuchwaldTahseen H NastiJudong LeeChristiane S EberhardtAndreas WielandSe Jin ImDavid LawsonWalter CurranRafi AhmedMohammad K KhanPublished in: Journal for immunotherapy of cancer (2021)
These correlative results suggest the tumor-draining LN may be an important mediator of the abscopal effect by serving as a stem-like CD8+ T-cell reservoir, a site for stem-like T-cell expansion, and a site from which they can populate the tumor.