Quantifiable TCR repertoire changes in pre-diagnostic blood specimens among high-grade ovarian cancer patients.

Xuexin YuJianfeng YeCassandra A HathawayShelley T TworogerJayanthi LeaBo Li

Published in: bioRxiv : the preprint server for biology (2023)

We made an unprecedented discovery that a strong and quantifiable change in the blood TCR repertoire occurs 4 to 2 years before high grade ovarian cancers could be diagnosed with conventional clinical tests. This finding might be useful to develop novel screening biomarkers to detect early-stage ovarian cancers.

Keyphrases

high throughput sequencing
high grade
early stage
low grade
regulatory t cells
small molecule
high throughput
squamous cell carcinoma
neoadjuvant chemotherapy
dendritic cells
single cell
fine needle aspiration
childhood cancer