Rapid One-Step 18F-Labeling of Peptides via Heteroaromatic Silicon-Fluoride Acceptors.
Maruthi Kumar NarayanamAnton A ToutovJennifer M MurphyPublished in: Organic letters (2020)
A new class of organosilicon-based radiosynthons, heteroaromatic silicon-fluoride acceptors, namely, HetSiFAs, that readily undergo isotope exchange with dry [18F]fluoride at room temperature in high radiochemical yield (up to 94%) with good molar activity is reported. Radiofluorination proceeds in a single step in 2 min without high-performance liquid chromatography purification to provide an operationally simple method for 18F-PET tracer production. This method was used to prepare an 18F-labeled commercial tetrapeptide, and positron emission tomography imaging confirmed in vivo stability.
Keyphrases
- positron emission tomography
- room temperature
- high performance liquid chromatography
- pet imaging
- computed tomography
- drinking water
- tandem mass spectrometry
- pet ct
- mass spectrometry
- solar cells
- simultaneous determination
- solid phase extraction
- high resolution
- ionic liquid
- gas chromatography
- photodynamic therapy
- loop mediated isothermal amplification