Acute bone loss following SARS-CoV-2 infection in mice.
Anne K HaudenschildBlaine A ChristiansenSophie OrrErin E BallChristopher M WeissHongwei LiuDavid P FyhrieJasper H N YikLark L CoffeyDominik R HaudenschildPublished in: Journal of orthopaedic research : official publication of the Orthopaedic Research Society (2023)
The novel coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has infected more than 650 million people worldwide. Approximately 23% of these patients developed lasting "long-haul" COVID symptoms, including fatigue, joint pain, and systemic hyperinflammation. However, the direct clinical impact of SARS-CoV-2 infection on the skeletal system including bone and joint health has not been determined. Utilizing a humanized mouse model of COVID-19, this study provides the first direct evidence that SARS-CoV-2 infection leads to acute bone loss, increased osteoclast number, and thinner growth plates. This bone loss could decrease whole-bone mechanical strength and increase the risk of fragility fractures, particularly in older patients, while thinner growth plates may create growth disturbances in younger patients. Evaluating skeletal health in patients that have recovered from COVID-19 will be crucial to identify at-risk populations and develop effective countermeasures.
Keyphrases
- sars cov
- coronavirus disease
- respiratory syndrome coronavirus
- bone loss
- end stage renal disease
- newly diagnosed
- mouse model
- ejection fraction
- healthcare
- chronic kidney disease
- mental health
- public health
- prognostic factors
- chronic pain
- type diabetes
- liver failure
- metabolic syndrome
- intensive care unit
- spinal cord
- risk assessment
- insulin resistance
- physical activity
- neuropathic pain
- spinal cord injury
- drug induced
- acute respiratory distress syndrome
- soft tissue
- monoclonal antibody
- bone regeneration