Diffusion and Perfusion MRI Predicts Response Preceding and Shortly After Radiosurgery to Brain Metastases: A Pilot Study.
Akash Deelip ShahAmaresha Shridhar KonarRamesh PaudyalJung Hun OhEve LoCastroDavid Aramburu NuñezNathaniel SwinburneBehroze VachhaGary A UlanerRobert J YoungAndrei I HolodnyKathryn BealAmita Shukla-DaveVaios HatzoglouPublished in: Journal of neuroimaging : official journal of the American Society of Neuroimaging (2020)
Quantitative DWI and DCE-MRI are feasible imaging methods in the pre- and early (within 72 hours) post-SRS evaluation of brain metastases. DWI- and DCE-MRI-derived parameters demonstrated physiologic changes (tumor cellularity and vascularity) and offer potentially useful biomarkers that can predict treatment response. This allows for initiation of alternate therapies within an effective time window that may help prevent disease progression.