Dysregulated skin barrier function in Tmem79 mutant mice promotes IL-17A-dependent spontaneous skin and lung inflammation.

Sean P Saunders Achilleas FloudasTara MoranCiara M ByrneMichael D RooneyCaoimhe M R FahyJoan A GeogheganYoichiro Iwakura Padraic G Fallon Christian Schwartz

Published in: Allergy (2020)

Mice lacking Tmem79/Mattrin expression have a defective skin barrier. In adulthood, these mice develop dermatitis with secondary progression to lung inflammation. The development of skin and lung inflammation is IL-17A-dependent and mediated by TCRγδ T cells.

Keyphrases

oxidative stress
soft tissue
wound healing
high fat diet induced
wild type
type diabetes
metabolic syndrome
regulatory t cells
dendritic cells
early life