Triquinane Sesquiterpene Glycosides from the Basidiomycete Antrodiella zonata .

In our ongoing study of fungal bioactive natural products, 12 previously undescribed triquinane sesquiterpene glycosides, namely, antrodizonatins A-L ( 1 - 12 ), and four known compounds ( 13 - 16 ) have been obtained from the fermentation of the basidiomycete Antrodiella zonata . The structures were established unambiguously via extensive spectroscopic analysis and theoretical calculations of electronic circular dichroism spectra. This is the first report of triquinane sesquiterpene glycosides. Compounds 1 , 5 , and 12 displayed antibacterial activity against Staphylococcus aureus with MIC 50 values of 35, 34, and 69 μM, respectively.