Cognitive phenotypes: Unraveling the heterogeneity in cognitive dysfunction among patients with primary brain tumors receiving radiotherapy.

Anny ReyesAlena StasenkoAustin HopperJiwandeep S KohliJonathan L HelmMia SalansDivya PrabhakaranLily KamalyanMolly WilkinsonSoumya UnnikrishnanRoshan KarunamuniJona A Hattangadi-GluthCarrie R McDonald

Published in: Neuro-oncology (2024)

We identified three distinct cognitive phenotypes in patients with primary brain tumors receiving RT, each associated with unique demographic and clinical (e.g., IDH mutational status) profiles, with mood symptoms associated with late cognitive decline. This patient-centered approach enhances our understanding of clinical profiles associated with cognitive dysfunction and treatment-related neurotoxicity.

Keyphrases

cognitive decline
mild cognitive impairment
early stage
bipolar disorder
sleep quality
radiation therapy
single cell
low grade
squamous cell carcinoma
locally advanced