Focused ultrasound-mediated blood-brain barrier opening is safe and feasible with moderately hypofractionated radiotherapy for brainstem diffuse midline glioma.

Masih TazhibiNicholas McQuillanHong-Jian WeiMatthew GallittoEthan BendauAndrea Webster CarrionXander BergDanae KokossisXu ZhangZhiguo ZhangChia-Ing JanAkiva MintzRobyn D GartrellHasan R SyedAdriana FonsecaJovana PavisicLuca SzalontayElisa E KonofagouStergios ZacharoulisCheng-Chia Wu

Published in: Journal of translational medicine (2024)

Repeated FUS-mediated BBBO is safe and feasible concurrent with RT. In our syngeneic DMG murine model, progression occurs, serving as an ideal model for future combination testing with RT and FUS-mediated drug delivery.

Keyphrases

blood brain barrier
drug delivery
radiation therapy
early stage
locally advanced
small cell lung cancer
cerebral ischemia
cancer therapy
current status
brain metastases