FK506 regulates Ca2+ release evoked by inositol 1,4,5-trisphosphate independently of FK-binding protein in endothelial cells.

Charlotte Buckley Calum Wilson John G McCarron

Published in: British journal of pharmacology (2020)

The hypertensive effects of the immunosuppressant drugs FK506 and rapamycin, while mediated by endothelial cells, do not appear to be exerted at the documented cellular targets of Ca2+ release and altered FKBP binding to IP3 and RyR.

Keyphrases

endothelial cells
binding protein
high glucose
blood pressure
vascular endothelial growth factor
protein kinase
drug induced