Combination of Pirfenidone and Andrographolide Ameliorates Hepatic Stellate Cell Activation and Liver Fibrosis by Mediating TGF- β /Smad Signaling Pathway.
Guang XuTidong MaChonggao ZhouFan ZhaoKun PengBixiang LiPublished in: Analytical cellular pathology (Amsterdam) (2024)
/Smad signaling pathway as compared to monotherapy. Therefore, the combination of PFD and AGP may be a promising treatment strategy for liver fibrosis in BA.
Keyphrases
- liver fibrosis
- signaling pathway
- epithelial mesenchymal transition
- transforming growth factor
- pi k akt
- combination therapy
- induced apoptosis
- single cell
- idiopathic pulmonary fibrosis
- cell therapy
- mouse model
- open label
- clinical trial
- stem cells
- oxidative stress
- bone marrow
- study protocol
- endoplasmic reticulum stress