IL15 and IL21: Better When Membrane-Tethered Together on Antitumor T Cells.

Ayana T Ruffin Megen C Wittling Anna C Cole Chrystal M Paulos

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

Systemic administration of homeostatic γ-chain cytokines mediates antitumor responses in some patients treated with adoptive immunotherapy. Yet many patients experience toxic side effects. New work presented herein suggests these limitations can be overcome by membrane-tethering IL15 and IL21 to T-cell products. This finding has major implications in advancing medicine. See related article by Nguyen et al., p. 1555.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
peritoneal dialysis
prognostic factors
cell therapy
bone marrow
drug induced