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Rapamycin attenuates pyroptosis by suppressing mTOR phosphorylation and promoting autophagy in LPS-induced bronchopulmonary dysplasia.

Feng ZhangMinrong WangZhongni LiJiehong DengYang FanZhixian GouYue ZhouLi HuangLiqun Lu
Published in: Experimental lung research (2023)
Rapamycin reduces pyroptosis in neonatal rats with LPS-induced BPD by inhibiting mTOR phosphorylation and inducing autophagy; hence, it may represent a potential therapeutic for treating BPD.
Keyphrases
  • lps induced
  • inflammatory response
  • signaling pathway
  • cell death
  • endoplasmic reticulum stress
  • nlrp inflammasome
  • cell proliferation
  • oxidative stress
  • protein kinase