Methylmercury-induced cytotoxicity and oxidative biochemistry impairment in dental pulp stem cells: the first toxicological findings.
Renata Duarte de Souza-RodriguesBruna PutyLaís BonfimLygia Sega NogueiraPriscila Cunha NascimentoLeonardo Oliveira BittencourtRoberta Souza D'Almeida CoutoCarlos Augusto Galvão BarbozaEdivaldo Herculano Correia de OliveiraMárcia Martins MarquesRafael Rodrigues LimaPublished in: PeerJ (2021)
It was observed that cell viability decreased significantly after exposure to 2.5 and 5 µM of MeHg, but the metabolic viability only decreased significantly at 5 µM MeHg exposure, accompanied by a significant decrease in GSH levels. These results suggest that an acute exposure of MeHg in concentrations higher than 2.5 µM has cytotoxic effects and reduction of antioxidant capacity on dental pulp stem cells.