To Investigate the Mechanism of Qinpi Tongfeng Formula in Treating Acute Gouty Arthritis by UHPLC-Q-Orbitrap-MS, Network Pharmacology and Experimental Validation.
Yi Hua FanWei LiuYue JinHang LuChunliu LiuAihua WangQingxiang GuYuxiu KaPublished in: Journal of inflammation research (2024)
Key targets of QPTFF include IL-1β, NFKBIA, IL-6, TNF-α, CXCL8, and MMP9. QPTFF effectively alleviates joint inflammation in AGA rats, with high doses demonstrating no liver or kidney toxicity. Its anti-inflammatory mechanism in treating AGA involves the IL-17A/NF-κB p65 signaling pathway.
Keyphrases
- signaling pathway
- oxidative stress
- ms ms
- mass spectrometry
- rheumatoid arthritis
- anti inflammatory
- pi k akt
- liver failure
- multiple sclerosis
- high resolution
- high resolution mass spectrometry
- mouse model
- respiratory failure
- induced apoptosis
- intensive care unit
- cell proliferation
- nuclear factor
- extracorporeal membrane oxygenation
- simultaneous determination
- gas chromatography