Nonalcoholic Fatty Liver Disease Is a Risk Factor for Thiopurine Hepatotoxicity in Crohn's Disease.

Alvin T GeorgeMatthew GloverQuazim AlayoMaria ZulfiqarDaniel R LudwigMatthew A CiorbaScott McHenryParakkal Deepak

Published in: Crohn's & colitis 360 (2023)

NAFLD at baseline is a risk factor for thiopurine-induced hepatotoxicity in patients with CD. The degree of liver fat positively correlated with the degree of ALT elevation. These data suggest that evaluation for hepatic steatosis be considered in patients with liver enzyme elevations with thiopurine therapy.

Keyphrases

drug induced
adipose tissue
high glucose
diabetic rats
electronic health record
big data
machine learning
bone marrow
artificial intelligence
smoking cessation