Research Progress on Nanoplatforms and Nanotherapeutic Strategies in Treating Glioma.
Li QiaoHuishu YangXin-Xin ShaoQiuyan YinXian-Jun FuQingcong WeiPublished in: Molecular pharmaceutics (2022)
Glioma is the most common and aggressive primary intracranial tumor within the central nervous system. The blood-brain barrier (BBB) has been a great hurdle for an effective glioma treatment. To effectively treat glioma, various strategies have been applied to deliver drugs to the brain by crossing the BBB. Nanocarrier-mediated drug delivery is emerging as an effective and noninvasive system to treat glioma, showing great potential in glioma therapy. In this review, we will provide a comprehensive overview on nanocarrier-mediated drug delivery and related glioma therapy. Following an initial overview of the BBB and blood-brain-tumor barrier (BBTB) structure and characteristics, nanocarrier-mediated drug delivery strategies (liposomes, micelles, inorganic systems, polymeric nanoparticles, nanogel system, biomimetic nanoparticles, and exosomes) for crossing the BBB are discussed. Finally, nanotherapeutic techniques (imaging-mediated chemotherapy, photothermal therapy, photodynamic therapy, gene therapy, immunotherapy, ferroptosis therapy, sonodynamic therapy, chemodynamic therapy, and combination therapy) in treating glioma are summarized. In addition, this review provides some perspectives on the clinical applications of nanomedicines.
Keyphrases
- drug delivery
- cancer therapy
- photodynamic therapy
- combination therapy
- drug release
- blood brain barrier
- gene therapy
- mesenchymal stem cells
- high resolution
- stem cells
- multiple sclerosis
- radiation therapy
- cell death
- bone marrow
- risk assessment
- squamous cell carcinoma
- brain injury
- resting state
- fluorescence imaging
- functional connectivity
- rectal cancer
- white matter
- replacement therapy