Heme oxygenase 1 facilitates cell proliferation via the B-Raf-ERK signaling pathway in melanoma.

Liu LiuYan WuChunxiang BianMuhammad Farrukh NisarMei WangXiangyu HuQingchun DiaoWeiqi NianEnwen WangWei XuJulia Li Zhong

Published in: Cell communication and signaling : CCS (2019)

Our result reveals a previously unknown mechanism that the HO-1-B-RAF-ERK axis plays an important role in melanoma cell proliferation. Therapeutic target on HO-1 could be a novel method for treating melanoma.

Keyphrases

pi k akt
cell proliferation
signaling pathway
skin cancer
cell cycle
induced apoptosis
oxidative stress
endoplasmic reticulum stress