ShRNA-mediated matrix metalloproteinase-2 gene silencing protects normal cells and sensitizes cancer cells against ionizing-radiation induced damage.

Gugalavath ShailenderKiranmayi PatanlaRama Rao Malla

Published in: Journal of cellular biochemistry (2019)

Results conclude that pMMP-2 protected HDFs from IR and sensitized the MCF-7 cells. Therefore, pMMP-2 can be employed for better treatment of radiation accidents and during the treatment of radiotherapy.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
endoplasmic reticulum stress
early stage
signaling pathway
combination therapy
high glucose
pi k akt