Regulation of the p53/SLC7A11/GPX4 Pathway by Gentamicin Induces Ferroptosis in HEI-OC1 Cells.

Yingying LiHui XuJinping ShiCong LiMengxin LiXiaoling ZhangQing XueJingjing QiuLimei CuiYan SunXicheng SongLiang Chen

Published in: Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology (2024)

Gentamicin induces ferroptosis in the HEI-OC1 cell line, and the mechanism may be related to the p53/SLC7A11/GPX4 signaling pathway.

Keyphrases

induced apoptosis
cell death
signaling pathway
cell cycle arrest
pi k akt
endoplasmic reticulum stress
epithelial mesenchymal transition
oxidative stress