Whole exome sequencing reveals the maintained polyclonal nature from primary to metastatic malignant peripheral nerve sheath tumor in two patients with NF1.
Abigail GodecReyka JayasingheJohn S A ChrisingerBethany PrudnerTyler BallYuxi WangDivya SrihariMadhurima KaushalHilary DietzXiaochun ZhangMelike PekmezciJeffrey R MillmanYu TaoJinqin LuoBrian A Van TineLi DingDavid H GutmannAngela C HirbePublished in: Neuro-oncology advances (2019)
The ability to track the genomic evolution from primary to metastatic MPNST offers new insights into the sequence of genetic events required for tumor progression and has identified TRIM23 as a novel target for future study in this rare cancer.