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Cyclosporine A alleviates colitis by inhibiting the formation of neutrophil extracellular traps via the regulating pentose phosphate pathway.

Chenjing XuZiping YeWenyu JiangShu WangHong-Jie Zhang
Published in: Molecular medicine (Cambridge, Mass.) (2023)
Our results indicated CsA could alleviate the severity of colitis by decreasing the formation of NETs in vivo. In vitro, CsA reduced ROS-dependent NETs release via downregulating PPP and cellular ROS levels by decreasing G6PD activity directly by activating the P53 protein.
Keyphrases
  • signaling pathway
  • cell death
  • dna damage
  • reactive oxygen species
  • ulcerative colitis
  • mouse model
  • small molecule