Therapeutic blockade of Foxp3 in experimental breast cancer models.

Mariela A Moreno AyalaMaría Florencia GottardoMercedes ImsenAntonela S AsadElisa Bal de Kier JofféNoelia CasaresJuan José LasarteAdriana SeilicovichMariela A Moreno Ayala

Published in: Breast cancer research and treatment (2017)

Our results suggest that Foxp3 blockade improves the therapeutic efficacy of DC vaccines by inhibition of Tregs and through a direct antitumor effect. This strategy could prove useful to neutralize the immunosuppressive microenvironment and to boost antitumor immunity in breast cancer.

Keyphrases

regulatory t cells
dendritic cells
stem cells
immune response
young adults